Azathioprine Impurity 11 CAS 4897-21-6

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.4897-21-6
Molecular FormulaC4H5ClN2
Molecular Weight116.55 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Azathioprine Impurity 11 CAS 4897-21-6 chemical structure

Description

CATO supplies Azathioprine Impurity 11 (CAS 4897-21-6), a pharmacopoeial impurity reference standard (molecular formula C4H5ClN2, MW 116.55 g/mol) used for the identification and quantification of trace impurities in APIs.

Azathioprine Impurity 11 (C4H5ClN2) contains a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC4H5ClN2
Molecular Weight116.55 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)3.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1958
Halogen ContentCl-containing
Nitrogen Atoms2

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