Haloperidol EP Impurity A CAS 3109-12-4
| CAS No. | 3109-12-4 |
| Molecular Formula | C21H24FNO2 |
| Molecular Weight | 341.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 341.42 g/mol gives Haloperidol EP Impurity A distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Haloperidol EP Impurity A (CAS 3109-12-4, C21H24FNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Haloperidol EP Impurity A (C21H24FNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H24FNO2 |
| Molecular Weight | 341.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Haloperidol Standards
- Haloperidol pyridinium Chloride Impurity (CAS 125785-69-5)
- Haloperidol Impurity 20 (CAS 185626-66-8)
- Haloperidol Impurity 39 (CAS 52669-92-8)
- Haloperidol Impurity 22 (CAS 660844-75-7)
- Haloperidol Impurity 33 (CAS 235109-63-4)
- Haloperidol EP Impurity B (CAS 1391052-53-1)
- Haloperidol (CAS 52-86-8)
- Haloperidol Impurity 15 (CAS CATO-C4X-146115)
Recommended Standards
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- Josamycin EP Impurity A (CAS 18361-46-1)
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- (Z)-3-(benzyloxy)benzaldehyde oxime (CAS 93033-58-0)
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- 2-Bromo-1-(2-fluoropyridin-4-yl)ethanone (CAS 1202854-31-6)
- Docetaxel Impurity 48 (CAS 1095547-90-2)
- D-[Phe]6-Liraglutide (CAS CATO-C4X-199235)
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