Methotrexate Impurity 17 HBr CAS 52853-40-4

Purity >80%In StockPharmacopoeial Impurity Standards
CAS No.52853-40-4
Molecular FormulaC7H7BrN6
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Methotrexate Impurity 17 HBr CAS 52853-40-4 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 335.99 g/mol gives Methotrexate Impurity 17 HBr distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

As a process- or degradation-related impurity, Methotrexate Impurity 17 HBr (CAS 52853-40-4, C7H7BrN6HBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Owing to a nitrile group, bromine substitution, an aromatic ring system, Methotrexate Impurity 17 HBr is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 335.99 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

CATO manufactures Methotrexate Impurity 17 HBr under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC7H7BrN6 HBr
Molecular Weight335.99 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity>80%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1972
Halogen ContentBr-containing
Nitrogen Atoms6

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