Abemaciclib Impurity 57 CAS CATO-C4X-293757
| CAS No. | CATO-C4X-293757 |
| Molecular Formula | C21H26F2N6 |
| Molecular Weight | 400.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C21H26F2N6, Abemaciclib Impurity 57 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 400.47 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Abemaciclib Impurity 57 (CAS CATO-C4X-293757, C21H26F2N6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Abemaciclib Impurity 57 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H26F2N6 |
| Molecular Weight | 400.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Abemaciclib Standards
- Abemaciclib Impurity 161 (CAS CATO-C4X-2937161)
- Abemaciclib Impurity 12 (CAS 1627082-92-1)
- Abemaciclib Impurity 92 (CAS CATO-C4X-293792)
- Abemaciclib Impurity 183 (CAS CATO-C4X-2937183)
- Abemaciclib Impurity 54 (CAS CATO-C4X-293754)
- Abemaciclib Impurity 13 (CAS 1648707-16-7)
- Abemaciclib Impurity 145 (CAS CATO-C4X-2937145)
- Abemaciclib Impurity 160 (CAS CATO-C4X-2937160)
Recommended Standards
- Vinorelbine Impurity 20 (CAS CATO-C4X-264220)
- DSR 6434 (CAS 1059070-10-8)
- Tolvaptan Impurity 22 (CAS CATO-C4X-195522)
- 2-(Cyclopentylthio)-1-(4-(difluoromethoxy)phenyl)-5-(p-tolyl)-1H-imidazole (CAS 1226445-50-6)
- Rupatadine impurity 48 (CAS 156611-76-6)
- Cefcapene Impurity 14 (CAS CATO-C4X-182414)
- Olaparib Impurity 71 (CAS 2592-95-2)
- (R)-2-((1-Acetylpiperidin-3-yl)(ethyl)amino)acetic acid (CAS 1353997-64-4)
- 3-(3-methoxyphenyl)-3-methylpyrrolidine hydrochloride (CAS 1236862-24-0)
- N-((1-((S)-2-Aminopropanoyl)pyrrolidin-2-yl)methyl)-N-ethylacetamide (CAS 1354025-43-6)
- 2-Hydroxy-4-methoxy-5-nitrobenzoic acid (CAS 723284-11-5)
- 2,3,4-Trichlorobenzonitrile (CAS 2112-31-4)
- 6-Ethyl-2-(3-methoxyphenyl)quinoline-4-carbonyl chloride (CAS 1160260-87-6)
- Tau Peptide (244-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 330456-24-1)
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