Loratadine Impurity 40 CAS 609806-37-3
| CAS No. | 609806-37-3 |
| Molecular Formula | C23H25ClN2O4 |
| Molecular Weight | 428.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Loratadine Impurity 40.
CATO supplies Loratadine Impurity 40 (CAS 609806-37-3), a pharmacopoeial impurity reference standard (molecular formula C23H25ClN2O4, MW 428.91 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Loratadine Impurity 40 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 428.91 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H25ClN2O4 |
| Molecular Weight | 428.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine impurity 21 (CAS CATO-C4X-142621)
- Loratadine impurity 22 (CAS CATO-C4X-142622)
- Loratadine EP Impurity 39 (CAS 609806-38-4)
- Loratadine Impurity 65 (CAS CATO-C4X-142665)
- Loratadine Impurity 81 (CAS CATO-C4X-142681)
- Loratadine Impurity 55 (CAS CATO-C4X-142655)
- Loratadine Impurity 53 (CAS CATO-C4X-142653)
- Loratadine Impurity 43 (CAS CATO-C4X-142643)
Recommended Standards
- Melphalan Impurity 27 (CAS CATO-C4X-198827)
- Capivasertib (CAS 1143532-39-1)
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- Bicalutamide Impurity 14 (Bicalutamide Epoxide Impurity) (CAS 90357-51-0)
- Canagliflozin Impurity 77 (CAS CATO-C4X-112377)
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- 4-(Dimethylamino)-2-phenylpyrimidine-5-carbonitrile (CAS 823795-59-1)
- (R)-1,1,1-trifluoro-3-(thietan-3-ylamino)propan-2-ol (CAS 1867481-18-2)
- 3-(Piperidin-3-yl)-1,2,4-oxadiazole hydrochloride (CAS 1609409-17-7)
- 5-Bromo-N-(2-(furan-3-yl)ethyl)nicotinamide (CAS 1797243-95-8)
- 6-Amino-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione (CAS 58481-39-3)
- Tirzepatide Impurity 58 (CAS CATO-C4X-324058)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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