Loratadine Impurity 43 CAS CATO-C4X-142643
| CAS No. | CATO-C4X-142643 |
| Molecular Formula | C25H31ClN4O |
| Molecular Weight | 438.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Loratadine Impurity 43 (CAS CATO-C4X-142643) is a certified pharmaceutical impurity reference standard with the molecular formula C25H31ClN4O and a molecular weight of 438.99 g/mol.
Based on its molecular formula C25H31ClN4O, Loratadine Impurity 43 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 438.99 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H31ClN4O |
| Molecular Weight | 438.99 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Loratadine Standards
- Loratadine Impurity 41 (CAS CATO-C4X-142641)
- Loratadine Impurity 53 (CAS CATO-C4X-142653)
- Loratadine Impurity 55 (CAS CATO-C4X-142655)
- Loratadine Impurity 81 (CAS CATO-C4X-142681)
- Loratadine Impurity 100 (CAS CATO-C4X-1426100)
- Loratadine impurity 21 (CAS CATO-C4X-142621)
- Loratadine impurity 22 (CAS CATO-C4X-142622)
- Loratadine EP Impurity 39 (CAS 609806-38-4)
Recommended Standards
- C-390 (CAS 77769-31-4)
- tert-butyl (2S)-2-((1R,2R)-3-(((2R)-1-chloro-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate (CAS CATO-CPTD789006)
- 1-Benzyl-3,4-diiodo-1H-pyrrole-2,5-dione (CAS 853649-55-5)
- 4-(4-tert-Butylphenoxy)-2-{[(2-chlorophenyl)methyl]sulfanyl}-5,6,7,8-tetrahydroquinazoline (CAS 339019-37-3)
- Neostigmine Impurity 5 (CAS 3743-22-4)
- Pranoprofen Impurity 41 (CAS CATO-C4X-181141)
- Etoricoxib Impurity 78 (CAS 99055-63-7)
- 4-Chloro-2-[4-(difluoromethoxy)phenyl]-5,6-dimethylthieno[2,3-d]pyrimidine (CAS 885460-87-7)
- 2-(1,3-benzodioxol-5-yloxy)thiazol-5-amine (CAS 1597650-17-3)
- 2-Amino-5-ethoxybenzaldehyde (CAS 70127-97-8)
- Remdesivir Impurity 32 (CAS CATO-C4X-210032)
- tert-butyl (2S)-2-formylpiperidine-1-carboxylate (CAS 150521-32-7)
- 1-(4-(1-Bromoethyl)phenyl)pyrrolidin-2-one (CAS 1710205-10-9)
- SV40 Nuclear Transport Signal Peptide Analog (CAS 104914-40-1)
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