Loratadine Impurity 81 CAS CATO-C4X-142681
| CAS No. | CATO-C4X-142681 |
| Molecular Formula | C26H27ClFN3 |
| Molecular Weight | 435.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Loratadine Impurity 81 (CAS CATO-C4X-142681) is a certified pharmaceutical impurity reference standard with the molecular formula C26H27ClFN3 and a molecular weight of 435.96 g/mol.
Based on its molecular formula C26H27ClFN3, Loratadine Impurity 81 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 435.96 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Loratadine Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H27ClFN3 |
| Molecular Weight | 435.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Loratadine Standards
- Loratadine Impurity 55 (CAS CATO-C4X-142655)
- Loratadine Impurity 53 (CAS CATO-C4X-142653)
- Loratadine Impurity 43 (CAS CATO-C4X-142643)
- Loratadine Impurity 41 (CAS CATO-C4X-142641)
- Loratadine Impurity 100 (CAS CATO-C4X-1426100)
- Loratadine impurity 21 (CAS CATO-C4X-142621)
- Loratadine impurity 22 (CAS CATO-C4X-142622)
- Loratadine EP Impurity 39 (CAS 609806-38-4)
Recommended Standards
- Ethyl 4-((4-chlorophenyl)sulfonyl)-1-(4-methylbenzyl)piperidine-4-carboxylate (CAS 866150-05-2)
- 4-((S)-((1S,2R,4S,5R)-1-(3-Chlorobenzyl)-5-vinylquinuclidin-1-ium-2-yl)(hydroxy)methyl)quinoline 1-oxide (CAS 1948286-02-9)
- tert-Butyl 1-(5-(1,3-dioxolan-2-yl)-2-methylthiophen-3-yl)-7-chloro-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 1858275-14-5)
- (E)-{[4-(4-chlorophenyl)-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,5-trien-3-yl]methylidene}[(3-methylphenyl)methoxy]amine (CAS 478041-80-4)
- Dasatinib Impurity 31 (CAS CATO-C4X-160731)
- Bisoprolol Impurity 118 (CAS 2919749-44-1)
- Cabozantinib Impurity 35 (CAS 2439164-91-5)
- 4-Cyclopropoxy-3-nitrobenzaldehyde (CAS 1243470-50-9)
- 3-Bromo-5-fluorobenzenethiol (CAS 179161-18-3)
- Ethyl 2-chloro-2-(2-(4-ethynylphenyl)hydrazono)acetate (CAS 1207062-37-0)
- Levofloxacin-d3 (CAS CATO-C4X-137150)
- (S)-2-(2-bromobenzyl)-3-((tert-butoxycarbonyl)amino)propanoic acid (CAS 1260592-51-5)
- 4-Nitro-N-((4-nitrophenyl)carbamothioyl)benzamide (CAS 19249-95-7)
- Semaglutide impurity 64 (CAS CATO-C4X-222664)
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