Erlotinib Impurity 106 CAS 6482-24-2
| CAS No. | 6482-24-2 |
| Molecular Formula | C3H7BrO |
| Molecular Weight | 138.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Erlotinib Impurity 106 (CAS 6482-24-2, C3H7BrO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a hydroxyl group, an ether linkage, bromine substitution, Erlotinib Impurity 106 is typically white to off-white liquid. Its solid-state physicochemical attributes — including a molecular weight of 138.99 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C3H7BrO |
| Molecular Weight | 138.99 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Stable under recommended storage conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Br-containing |
Related Erlotinib Standards
- Erlotinib Impurity 117 (CAS 139-85-5)
- Erlotinib Impurity 112 (CAS 99-03-6)
- Erlotinib Impurity 24 (CAS 134690-40-7)
- Erlotinib Impurity 113 (CAS 587-02-0)
- Erlotinib Impurity 122 (CAS 1709-44-0)
- Erlotinib Impurity 116 (CAS 15411-43-5)
- Erlotinib Impurity 114 (CAS 14235-81-5)
- Erlotinib Impurity 115 (CAS 52670-38-9)
Recommended Standards
- 3-Bromo-1-propanol (CAS 627-18-9)
- 2-Bromo-1-propanol (CAS 598-18-5)
- (bromomethoxy)ethane (CAS 53588-92-4)
- 1-Bromo-2-propanol (contains ca. 20% 2-Bromo-1-propanol) (stabilized with MgO) (CAS 19686-73-8)
- Ambroxol Impurity 66 (CAS CATO-C4X-108566)
- Bisoprolol Impurity 29 (CAS 1797024-50-0)
- rac-Melphalan EP Impurity B (CAS 1259994-01-8)
- 2-(4,4-Difluoropiperidin-1-yl)ethan-1-ol hydrochloride (CAS 2097872-93-8)
- Nitromethane-<SUP>13</SUP>C,d<SUB>3</SUB> (CAS 112898-45-0)
- N-({7-azabicyclo[2.2.1]heptan-1-yl}methylidene)-2-methylpropane-2-sulfinamide (CAS 2226198-69-0)
- 5-Chloro-indan-2-ylamine hydrochloride (CAS 73536-86-4)
- ethyl 2-amino-5-methylpyrimidine-4-carboxylate (CAS 1700175-48-9)
- 28123-73-1 AR-1K4860 n-{5-[(3-{[n5-(diaminomethylidene)ornithyl]amino}propyl)amino]pentyl}-n2-[(4-hydroxy-1h-indol-3-yl)acetyl]-n6-methyllysinamide (CAS 28123-73-1)
- D-Tyr10-Tirzepatide (CAS CATO-CPTD788922)
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