Everolimus Impurity 1 CAS 745779-75-3
| CAS No. | 745779-75-3 |
| Molecular Formula | C52H81NO14 |
| Molecular Weight | 944.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C52H81NO14, Everolimus Impurity 1 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 944.20 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Everolimus Impurity 1 (CAS 745779-75-3) is a certified pharmaceutical impurity reference standard with the molecular formula C52H81NO14 and a molecular weight of 944.20 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C52H81NO14 |
| Molecular Weight | 944.20 g/mol |
| Purity | >80% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 1 |
Related Everolimus Standards
- Everolimus Impurity 13 (CAS CATO-C4X-112213)
- Everolimus EP Impurity C (CAS CATO-C4X-112231)
- Everolimus EP Impurity E (CAS 1237826-25-3)
- Everolimus Impurity 49 (CAS CATO-C4X-112249)
- Everolimus Impurity 30 (CAS CATO-C4X-112230)
- Everolimus EP Impurity B (CAS 1062122-63-7)
- Everolimus Ring-Opening Impurity (Mixture of Isomers) (CAS 1708118-13-1)
- Everolimus Impurity 33 (CAS 908340-97-6)
Recommended Standards
- 1,3,5,7-tetrakis(4-iodophenyl)adamantane (CAS 144970-30-9)
- K-Ras ligand-Linker Conjugate 3 (CAS 2378261-87-9)
- 9'-(4-(4,6-Diphenyl-1,3,5-triazin-2-yl)phenyl)-3,3'',6,6''-tetraphenyl-9'H-9,3':6',9''-tercarbazole (CAS 1620808-43-6)
- 1,3,5,7-Tetrakis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)adamantane (CAS 1636119-48-6)
- Imatinib Impurity 18 (CAS 112696-91-0)
- Glycyrrhizic Acid Impurity 23 (CAS CATO-C4X-253723)
- Ozagrel Impurity 29 (CAS 94084-75-0)
- 3-(((3-Methoxyphenyl)thio)methyl)-4-phenyl-1-(p-tolyl)azetidin-2-one (CAS 866049-19-6)
- 4-Bromo-2-nitronaphthalen-1-ol (CAS 905302-18-3)
- 2-cyclobutyl-1,3-oxazole-4-carbonitrile (CAS 1190314-22-7)
- 4-(4-AMINOPHENYL)PIPERIDINE 2HCL (CAS 1159824-20-0)
- tert-Butyl (2S,4S)-2-(5-chloro-3-(3-fluorophenyl)-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-fluoropyrrolidine-1-carboxylate (CAS 1551158-99-6)
- 1-(4-Methoxy-2-methylphenyl)-3-methylbutan-1-one (CAS 71898-87-8)
- Semaglutide impurity 72 (CAS CATO-C4X-222672)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com