Argatroban Impurity 33 CAS 74874-08-1
| CAS No. | 74874-08-1 |
| Molecular Formula | C15H28N6O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Argatroban Impurity 33 (CAS 74874-08-1, C15H28N6O5HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Argatroban Impurity 33 (C15H28N6O5HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H28N6O5 HCl |
| Molecular Weight | 408.88 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Argatroban Standards
- Argatroban Impurity 78 (CAS 121785-71-5)
- Argatroban Impurity 79 (CAS 121785-72-6)
- Argatroban Impurity 80 (CAS 1260981-49-4)
- Argatroban Impurity 23 (CAS 1356847-56-7)
- Argatroban (CAS 141396-28-3)
- Argatroban Impurity 10 (CAS 1448301-07-2)
- Argatroban Impurity 109 (CAS 1515961-07-5)
- Argatroban Impurity 95 (CAS 153886-68-1)
Recommended Standards
- Lifitegrast Impurity 137 (CAS CATO-C4X-2409137)
- Bosutinib Impurity N8 (CAS 42252-34-6)
- Empagliflozin impurity 268 (CAS CATO-C4X-1065268)
- Desmethyl Atomoxetine-d7 Hydrochloride Salt (CAS 1189961-95-2)
- 2-Cyclobutyl-2-methylpropanoic acid (CAS 1603359-47-2)
- Ribociclib Impurity 25 (CAS CATO-C4X-310025)
- 2-(5-fluorothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1253586-81-0)
- 3-Fluoro-2-(trifluoromethoxy)aniline (CAS 1806378-59-5)
- Fluvoxamine Impurity 27 (CAS CATO-C4X-195127)
- CBP501 Affinity Peptide trifluoroacetate salt (CAS 1351804-17-5)
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