Flumazenil EP Impurity F CAS 78756-33-9
| CAS No. | 78756-33-9 |
| Molecular Formula | C15H14ClN3O3 |
| Molecular Weight | 319.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Flumazenil EP Impurity F (C15H14ClN3O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 319.74 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Flumazenil EP Impurity F (CAS 78756-33-9) is a certified pharmaceutical impurity reference standard with the molecular formula C15H14ClN3O3 and a molecular weight of 319.74 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H14ClN3O3 |
| Molecular Weight | 319.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Flumazenil Standards
- Flumazenil Impurity 16 (CAS CATO-C4X-143216)
- Flumazenil Impurity 15 (CAS CATO-C4X-143215)
- Flumazenil Impurity 17 (CAS CATO-C4X-143217)
- Flumazenil Impurity 18 (CAS CATO-C4X-143218)
- Flumazenil-D5 (CAS 2700278-14-2)
- Flumazenil (CAS 78755-81-4)
- Flumazenil Impurity 12 (CAS CATO-C4X-143212)
- Flumazenil EP Impurity B (CAS 131666-45-0)
Recommended Standards
- Amlodipine Impurity 156 (CAS CATO-C4X-1095156)
- Bezafibrate Impurity 7 (CAS CATO-C4X-20177)
- Sarmazenil (CAS 78771-13-8)
- 2-(1H-1,3-Benzodiazol-2-yl)-4-chloro-5-[(3-hydroxypropyl)amino]-2,3-dihydropyridazin-3-one (CAS 726152-52-9)
- Pimavanserin Impurity 52 (CAS CATO-C4X-193852)
- (Z)-Ceftizoxime Impurity 19 (CAS CATO-C4X-179319)
- Tigecycline Impurity 20 (CAS 866602-58-6)
- 2-(2-Ethoxyethoxy)-5-fluoroaniline (CAS 946774-73-8)
- (R)-methyl 2-isocyanatopropanoate (CAS 30293-81-3)
- 2-Formylnicotinic acid hydrate (CAS 2007908-74-7)
- 6,11-Dihydro-5H-dipyrido[2,3-b:4,3-f]-azepin-5-one (CAS 933768-16-2)
- 5-Bromo-3-cyclopropylisoxazole (CAS 1263378-59-1)
- Diethyl Ethylphosphonate (CAS 78-38-6)
- Semaglutide impurity 87 (CAS CATO-C4X-222687)
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