Enzalutamide Impurity N4 CAS 869936-86-7
| CAS No. | 869936-86-7 |
| Molecular Formula | C8H9FN2O |
| Molecular Weight | 168.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Enzalutamide Impurity N4 (C8H9FN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Enzalutamide Impurity N4 (CAS 869936-86-7) is a certified pharmaceutical impurity reference standard with the molecular formula C8H9FN2O and a molecular weight of 168.17 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9FN2O |
| Molecular Weight | 168.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Enzalutamide Standards
- Enzalutamide Impurity 19 (CAS 73792-08-2)
- Enzalutamide Impurity 21 (CAS 446-31-1)
- Enzalutamide Impurity 20 (CAS 1187368-67-7)
- Enzalutamide Impurity 24 (CAS 403-24-7)
- Enzalutamide Impurity 22 (CAS 392-09-6)
- Enzalutamide Impurity 36 (CAS 208122-06-9)
- Enzalutamide Impurity 33 (CAS 934600-95-0)
- Enzalutamide Impurity 35 (CAS 888072-96-6)
Recommended Standards
- Dimethyl(4-methylphenyl)phosphine oxide (CAS 53888-89-4)
- imidazo[2,1-b][1,3]thiazole-2-carboxylic acid (CAS 773841-78-4)
- 6-O-Methyl-d (CAS 50704-43-3)
- imidazo[2,1-b][1,3]thiazole-3-carboxylic acid (CAS 479028-73-4)
- Ibuprofen Impurity N18 (CAS 126176-61-2)
- Citalopram Impurity 21 (CAS 1433278-32-0)
- Tolvaptan Impurity 73 (CAS 1316312-24-9)
- Dicyclohexylammonium (S)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate (CAS 4677-75-2)
- (Z)-2-(4-(3-(2,6-dichlorobenzyl)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-3-(dimethylamino)acrylonitrile (CAS 400074-55-7)
- 2-((4-Methyl-2-nitrophenoxy)methyl)thiazolidine (CAS 675854-56-5)
- 2-(2-(4-Methylpiperazin-1-yl)pyridin-3-yl)piperidine-1-carbaldehyde (CAS 1352483-03-4)
- 2-Methoxy-4-(thiazolidin-2-yl)phenol (CAS 98896-96-9)
- 4-Methylquinolin-3-amine (CAS 50878-90-5)
- Semaglutide impurity 43 (CAS CATO-C4X-222643)
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