Empagliflozin Impurity 78 CAS 874817-93-3
| CAS No. | 874817-93-3 |
| Molecular Formula | C7H4ClIO2 |
| Molecular Weight | 282.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Empagliflozin Impurity 78 (CAS 874817-93-3, C7H4ClIO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/iodine substitution, an aromatic ring system, Empagliflozin Impurity 78 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 282.46 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Empagliflozin Impurity 78 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4ClIO2 |
| Molecular Weight | 282.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 28 (CAS 19094-56-5)
- Empagliflozin Impurity 173 (CAS 46698-24-2)
- Empagliflozin Impurity 2 (CAS 2517968-35-1)
- Empagliflozin Impurity 03 (CAS 312749-31-8)
- Empagliflozin Impurity 174 (CAS 270903-87-2)
- Empagliflozin Impurity 33 (CAS CATO-C4X-106533)
- Empagliflozin Impurity 90 (CAS 620621-48-9)
- Empagliflozin impurity 56 (CAS 1628918-33-1)
Recommended Standards
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- 4-Methyl-2-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)thiazole-5-carboxylic acid (CAS 1072802-47-1)
- 4-chloro-5-hydroxy-pyridine-2-carboxylic acid (CAS 1060804-56-9)
- 2-BROMO-5-CHLOROBENZOIC ACID 394-30-9 5-CHLORO-2-BROMOBENZOIC ACID 5-Chloro-2-fluorobenzoic acid 6-BROMO-3-CHLOROBENZOIC ACID BENZOIC ACID, 2-BROMO-5-CHLORO- LF10797 (CAS 394-30-9)
- Methyl 10-aminodecanoate hydrochloride (CAS 150840-94-1)
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