Ponatinib Active Metabolite AP24567(M42) CAS 943319-87-7
| CAS No. | 943319-87-7 |
| Molecular Formula | C28H25F3N6O |
| Molecular Weight | 518.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ponatinib Active Metabolite AP24567(M42) (CAS 943319-87-7) is a high-purity analytical reference standard with the molecular formula C28H25F3N6O and a molecular weight of 518.53 g/mol.
The molecular framework of Ponatinib Active Metabolite AP24567(M42) (C28H25F3N6O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H25F3N6O |
| Molecular Weight | 518.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Ponatinib Standards
- Ponatinib Impurity 54 (CAS CATO-C4X-226954)
- Ponatinib Impurity 43 (E-Isomer) (CAS CATO-C4X-226943)
- Ponatinib Impurity 44 (Z-Isomer) (CAS CATO-C4X-226944)
- Ponatinib (CAS 943319-70-8)
- Ponatinib Impurity 15 (E-Isomer) (CAS CATO-C4X-226915)
- Ponatinib Impurity 18 (Z-Isomer) (CAS CATO-C4X-226918)
- Ponatinib-d8 (CAS 1562993-37-6)
- Ponatinib Impurity 11 (CAS CATO-C4X-226911)
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- Potassium Bis(nonafluorobutanesulfonyl)imide (CAS 129135-87-1)
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