Hydrochlorothiazide Impurity 29 CAS 957785-35-2

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.957785-35-2
Molecular FormulaC6H5ClN2O4S
Molecular Weight236.63 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Hydrochlorothiazide Impurity 29 CAS 957785-35-2 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 236.63 g/mol gives Hydrochlorothiazide Impurity 29 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Hydrochlorothiazide Impurity 29 (CAS 957785-35-2), a pharmacopoeial impurity reference standard (molecular formula C6H5ClN2O4S, MW 236.63 g/mol) used for the identification and quantification of trace impurities in APIs.

Owing to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Hydrochlorothiazide Impurity 29 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 236.63 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Hydrochlorothiazide Impurity 29 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC6H5ClN2O4S
Molecular Weight236.63 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, ethanol, DMSO, water
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1987
Halogen ContentCl-containing
Nitrogen Atoms2
Sulfur Atoms1

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