Carfilzomib Impurity 72 CAS CATO-C4X-102272
| CAS No. | CATO-C4X-102272 |
| Molecular Formula | C40H59N5O8 |
| Molecular Weight | 737.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Carfilzomib Impurity 72.
Carfilzomib Impurity 72 (CAS CATO-C4X-102272) is a certified pharmaceutical impurity reference standard with the molecular formula C40H59N5O8 and a molecular weight of 737.93 g/mol.
The molecular framework of Carfilzomib Impurity 72 (C40H59N5O8) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C40H59N5O8 |
| Molecular Weight | 737.93 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Carfilzomib Standards
- Carfilzomib Impurity 41 (CAS CATO-C4X-102241)
- Carfilzomib Impurity 42 (CAS CATO-C4X-102242)
- Carfilzomib Impurity 48 (CAS 1541172-75-1)
- Carfilzomib Impurity 50 (CAS CATO-C4X-102250)
- Carfilzomib Impurity D3 (CAS CATO-C4X-102258)
- Carfilzomib Impurity D4 (CAS CATO-C4X-102259)
- Carfilzomib Impurity 63 (CAS CATO-C4X-102263)
- Carfilzomib Impurity 67 (CAS CATO-C4X-102267)
Recommended Standards
- Carfilzomib Impurity 71 (CAS CATO-C4X-102271)
- Carfilzomib Impurity 73 (CAS CATO-C4X-102273)
- Carfilzomib Impurity 70 (CAS CATO-C4X-102270)
- Erythromycin-13C,d3 (CAS 2378755-50-9)
- Doxycycline Hyclate EP Impurity F (CAS CATO-C4X-19319)
- Sacubitril impurity 52 (CAS CATO-C4X-280952)
- Brimonidine Impurity 7 (CAS CATO-C4X-15667)
- 7-Iodo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine (CAS 957194-13-7)
- 1-(4-Methoxybenzyl)-6-((trimethylsilyl)ethynyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (CAS 1198425-56-7)
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- 2-(2-Mercapto-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)-N-(4-methoxyphenyl)acetamide (CAS 1142206-71-0)
- 5,6,7,8-Tetrahydro-1,3-Dioxolo[4,5-g]isoquinoline Hydrochloride (CAS 15052-05-8)
- 1-(1-Acetylpiperidin-4-yl)-1h-pyrazole-4-carboxylic acid (CAS 1365988-19-7)
- (Des-Gly2)-Exenatide trifluoroacetate salt (CAS 1678416-78-8)
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