Ibrutinib Impurity 194 CAS CATO-C4X-1064194
| CAS No. | CATO-C4X-1064194 |
| Molecular Formula | C28H28N6O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ibrutinib Impurity 194.
As a process- or degradation-related impurity, Ibrutinib Impurity 194 (CAS CATO-C4X-1064194, C28H28N6O4C2HF3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C28H28N6O4C2HF3O2, Ibrutinib Impurity 194 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 626.59 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ibrutinib Impurity 194 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H28N6O4 C2HF3O2 |
| Molecular Weight | 626.59 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 47 (CAS 1022150-11-3)
- Ibrutinib Impurity 10 (CAS 1022150-12-4)
- Ibrutinib Impurity 80 (CAS 109384-19-2)
- Ibrutinib Impurity 53 (CAS 109831-68-7)
- Ibrutinib Impurity 54 (CAS 1260862-85-8)
- Ibrutinib Impurity 4 (CAS 1288338-95-3)
- Ibrutinib Impurity 3 (CAS 1288338-96-4)
- Ibrutinib Impurity 81 (CAS 143667-36-1)
Recommended Standards
- Valsartan Impurity 28 (CAS 154709-17-8)
- Lasmiditan Impurity 43 (CAS CATO-C4X-247843)
- Lifitegrast Impurity 110 (CAS 2091680-73-6)
- Methyl 3-amino-3-ethylpentanoate (CAS 1376286-53-1)
- 3-Iodo-1,1,1-trifluoroheptane (CAS 89608-37-7)
- 3-benzyl-8-methyl-3-azabicyclo[3.2.1]octan-8-ol (CAS 1331846-58-2)
- N-(2-hydroxyphenyl)cyclopropanecarboxamide (CAS 883244-95-9)
- 9-Hydrazinyl-4-methylacridine (CAS 110701-29-6)
- (2S,4R)-1-(tert-butoxycarbonyl)-4-(trifluoromethyl)azetidine-2-carboxylic acid (CAS 2166011-73-8)
- Peptide Impurity 40 (CAS CATO-CPTD788840)
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