Imatinib Impurity 65 CAS CATO-C4X-106865
| CAS No. | CATO-C4X-106865 |
| Molecular Formula | C24H19Cl2N5O |
| Molecular Weight | 464.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Imatinib Impurity 65 (CAS CATO-C4X-106865, C24H19Cl2N5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Imatinib Impurity 65 (C24H19Cl2N5O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H19Cl2N5O |
| Molecular Weight | 464.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Imatinib Standards
- Imatinib Impurity 73 (CAS CATO-C4X-106873)
- Imatinib Impurity 70 (CAS CATO-C4X-106870)
- Imatinib Impurity 67 (CAS 2031255-25-9)
- Imatinib EP Impurity C (CAS 404844-02-6)
- Imatinib Impurity 87 (CAS 571187-02-5)
- Imatinib EP Impurity C-d8 (N-Desmethyl Imatinib-d8) (CAS 1185103-28-9)
- Imatinib Impurity 10 (CAS 1026753-54-7)
- Imatinib (CAS 152459-95-5)
Recommended Standards
- (Z)-N-(1-Bromo-3-oxo-3-(piperidin-1-yl)-1-(quinolin-3-yl)prop-1-en-2-yl)benzamide (CAS 1800044-72-7)
- Pyrifluquinazon (CAS 337458-27-2)
- Tizanidine EP Impurity F (CAS 1147548-85-3)
- Diethyl 4-(5-(3,4-dichlorophenyl)furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS 301306-01-4)
- Carbocisteine Impurity 25 (CAS CATO-C4X-201025)
- Ambroxol EP Impurity D HCl (CAS 1384955-66-1)
- Allisartan Isoproxil Impurity 3 (CAS CATO-C4X-32173)
- 7-Amino-4-chloropyrido[2,3-d]pyrimidine (CAS 1423034-11-0)
- 5,7-Bis(trifluoromethyl)quinoline-4-thiol (CAS 1065076-04-1)
- ethyl (2,2,2-trifluoroethyl) oxalate (CAS 1269151-38-3)
- 4-Chloro-5-((3-chlorobenzyl)oxy)-2-propylpyridazin-3(2H)-one (CAS 88094-04-6)
- N-(3,5-Bis(trifluoromethyl)phenyl)-3-ethynylbenzamide (CAS 2499499-14-6)
- 2-(Difluoromethyl)pyridine (CAS 114468-01-8)
- Peptide Impurity 41 (CAS CATO-CPTD788841)
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