Fosaprepitant Impurity 50 CAS CATO-C4X-116850
| CAS No. | CATO-C4X-116850 |
| Molecular Formula | C23H23F6N4O6P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Fosaprepitant Impurity 50 (CAS CATO-C4X-116850), a pharmacopoeial impurity reference standard (molecular formula C23H23F6N4O6PC7H17NO5, MW 791.64 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Fosaprepitant Impurity 50 (C23H23F6N4O6PC7H17NO5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C23H23F6N4O6P 2*C7H17NO5 |
| Molecular Weight | 791.64 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Fosaprepitant Standards
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Recommended Standards
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- N-{1-[(4-chlorophenyl)methyl]-1-cyanoethyl}acetamide (CAS 2059937-38-9)
- 7-Methyl-7-azaspiro[3.5]Nonane-2-carboxylic acid (CAS 1782344-10-8)
- 5-(Hydroxy(5-methylfuran-2-yl)methylene)thiazolidine-2,4-dione (CAS 404008-46-4)
- 4-Oxopentanenitrile (CAS 927-56-0)
- 6-cyclopropyl-1-ethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 954261-91-7)
- Tirzepatide Impurity 22 X TFA Salt (CAS CATO-C4X-324022)
Why CATO?
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