Fosaprepitant impurity 57（S,R,R） CAS CATO-C4X-116857
| CAS No. | CATO-C4X-116857 |
| Molecular Formula | C23H22F7N4O6P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 809.63 g/mol gives Fosaprepitant impurity 57（S,R,R） distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Fosaprepitant impurity 57（S,R,R） (CAS CATO-C4X-116857) is a certified pharmaceutical impurity reference standard with the molecular formula C23H22F7N4O6PC7H17NO5 and a molecular weight of 809.63 g/mol.
Structurally, Fosaprepitant impurity 57（S,R,R） (C23H22F7N4O6PC7H17NO5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.5, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 809.63 g/mol, it falls into the high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H22F7N4O6P 2*C7H17NO5 |
| Molecular Weight | 809.63 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Fosaprepitant Standards
- Fosaprepitant impurity 55（R,S,R） (CAS 1185503-00-7(free base))
- Fosaprepitant Impurity 53 (CAS 1254261-32-9)
- Fosaprepitant Impurity 4 Dimeglumine (CAS 1523569-87-0)
- Fosaprepitant Impurity 19 (CAS 1623-07-0)
- Fosaprepitant Impurity 48 (CAS 1707-92-2)
- Fosaprepitant Impurity 6 (CAS 172822-01-4（free base）)
- Fosaprepitant Impurity 12 (CAS 2035475-10-4)
- Fosaprepitant Impurity 41 HCl (CAS 2377328-02-2)
Recommended Standards
- Vardenafil Impurity 52 (CAS 224789-22-4)
- Venetoclax Impurity 151 (CAS CATO-C4X-2495151)
- Xanomeline Impurity 38 (CAS CATO-C4X-330138)
- 2'-Methyl-[1,1'-biphenyl]-2-amine hydrochloride (CAS 1203-42-5)
- 6-Bromo-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide (CAS 1341686-40-5)
- 1-[1-(4-Methylphenyl)-6-(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]pyrrolidine (CAS 478247-43-7)
- Ethyl 2-amino-4-methylpyrimidine-5-carboxylate (CAS 81633-29-6)
- 2-Azabicyclo[2.2.1]heptan-3-one (CAS 24647-29-8)
- Bisoprolol Fumarate (CAS 105878-43-1)
- CGMP Dependent Kinase Inhibitor Peptide (CAS 82801-73-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com