Isavuconazole impurity 66 CAS CATO-C4X-1236166
| CAS No. | CATO-C4X-1236166 |
| Molecular Formula | C14H16F2O3 |
| Molecular Weight | 270.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Isavuconazole impurity 66 (CAS CATO-C4X-1236166, C14H16F2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Isavuconazole impurity 66 (C14H16F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H16F2O3 |
| Molecular Weight | 270.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Isavuconazole Standards
- Isavuconazole impurity 68 (CAS CATO-C4X-1236168)
- Isavuconazole impurity 69 (CAS CATO-C4X-1236169)
- Isavuconazole impurity 70 (CAS CATO-C4X-1236170)
- Isavuconazole impurity 72 (CAS CATO-C4X-1236172)
- Isavuconazole Impurity 213 (CAS CATO-C4X-1236213)
- Isavuconazole Impurity 1 (CAS 2069200-13-9)
- Isavuconazole Impurity 108 (CAS CATO-C4X-1236108)
- Isavuconazole Impurity 158 (CAS CATO-C4X-1236158)
Recommended Standards
- Posaconazole Impurity 98 (CAS CATO-C4X-120898)
- Efinaconazole Impurity 35 (CAS 127001-03-0)
- Tedizolid Impurity 29 (CAS 1638760-07-2)
- Azathioprine Impurity 15 (CAS 90947-51-6)
- Bicalutamide EP Impurity B (CAS 1159977-36-2)
- Terfenadine EP Impurity A (CAS 43076-30-8)
- Bendamustine Impurity 30 (CAS CATO-C4X-127130)
- 2-(Diethoxymethyl)oxazole (CAS 1263280-97-2)
- 5-tert-butyl-3-chloro-1,2,4-oxadiazole (CAS 1393540-56-1)
- [(6-methylpyridin-2-yl)methyl](prop-2-yn-1-yl)amine (CAS 1248915-22-1)
- tert-butyl (4S)-4-hydroxyisoxazolidine-2-carboxylate (CAS 878385-72-9)
- Benserazide Impurity 10 (CAS CATO-C4X-142710)
- α-Phenyl-α-(trifluoromethyl)-1H-pyrrole-2-methanol (CAS 4156-00-7)
- Semaglutide impurity 86 (CAS CATO-C4X-222686)
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