Nilotinib Impurity 36 HCl CAS CATO-C4X-125636
| CAS No. | CATO-C4X-125636 |
| Molecular Formula | C12H12F3N3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Nilotinib Impurity 36 HCl (CAS CATO-C4X-125636), a pharmacopoeial impurity reference standard (molecular formula C12H12F3N3HCl, MW 291.70 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C12H12F3N3HCl, Nilotinib Impurity 36 HCl contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 291.70 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Nilotinib Impurity 36 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12F3N3 HCl |
| Molecular Weight | 291.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Nilotinib Standards
- Nilotinib Impurity N1 Nitrate salt (CAS 1025716-99-7)
- Nilotinib Genotoxic Impurity 2 (CAS 1157857-29-8)
- Nilotinib-d3 (CAS 1215678-43-5)
- Nilotinib N-Oxide (CAS 1246817-85-5)
- Nilotinib-d6 (CAS 1268356-17-7)
- Nilotinib Impurity A (CAS 1345336-53-9)
- Nilotinib Impurity 47 (CAS 1807606-80-9)
- Nilotinib Impurity 46 (CAS 1807607-72-2)
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