Nebivolol Impurity 58 CAS CATO-C4X-196858
| CAS No. | CATO-C4X-196858 |
| Molecular Formula | 2*C22H26FNO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nebivolol Impurity 58.
CATO supplies Nebivolol Impurity 58 (CAS CATO-C4X-196858), a pharmacopoeial impurity reference standard (molecular formula C22H26FNO4, MW 387.45 g/mol) used for the identification and quantification of trace impurities in APIs.
Nebivolol Impurity 58 (C22H26FNO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nebivolol Impurity 58 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C22H26FNO4 |
| Molecular Weight | 387.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 66 (CAS 1017878-67-9)
- Nebivolol Impurity 15 (CAS 1029684-20-5)
- Nebivolol Impurity 20 (CAS 105300-40-1)
- Nebivolol Impurity 28 (CAS 112068-01-6)
- D-Nebivolol (SR,RR) (CAS 118457-15-1)
- L-Nebivolol (RS,SS) (CAS 118457-16-2)
- Nebivolol Hydrochloride EP Impurity B (CAS 119365-23-0)
- Nebivolol Impurity 32（SS,RS）or（SR,SS） (CAS 119365-25-2)
Recommended Standards
- Trametinib impurity 13 (CAS CATO-C4X-278213)
- Cefixime Impurity 41 (CAS CATO-C4X-113941)
- Nicotine impurity 16 (CAS CATO-C4X-201916)
- (3R,6R)-3,6-Bis(hydroxymethyl)piperazine-2,5-dione (CAS 20945-52-2)
- 3-[1-(4-chlorophenyl)-2,5-dioxoimidazolidin-4-yl]propanoic acid (CAS 1173293-40-7)
- N-(4-Chlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 5334-66-7)
- 2-Cyclopropyl-4-isopropoxy-6-methoxypyrimidine (CAS 552882-10-7)
- n-Phenethyl-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide (CAS 304888-44-6)
- 8-Chloro-4-methylquinolin-2(1H)-one (CAS 54904-38-0)
- Peptide Impurity 13 (CAS CATO-CPTD788813)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com