Trametinib impurity 13 CAS CATO-C4X-278213
| CAS No. | CATO-C4X-278213 |
| Molecular Formula | C26H20F2I2N6O4 |
| Molecular Weight | 772.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Trametinib impurity 13 (CAS CATO-C4X-278213, C26H20F2I2N6O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Trametinib impurity 13 (C26H20F2I2N6O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Trametinib impurity 13 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H20F2I2N6O4 |
| Molecular Weight | 772.28 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 6 |
Related Trametinib Standards
- Trametinib Impurity N10 (CAS 1383430-04-3)
- Trametinib impurity 02 (CAS 871700-32-2)
- Trametinib Impurity 19 (CAS CATO-C4X-278219)
- Trametinib Impurity N2 (CAS 871701-39-2)
- Trametinib impurity 18 (CAS 1383430-03-2)
- Trametinib impurity 26 (CAS CATO-C4X-27826)
- Trametinib-13C-d3 (CAS 2712126-59-3)
- Trametinib impurity 04 (CAS 871700-25-3)
Recommended Standards
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-n,n-dimethyl 96687-22-8 (CAS 96687-22-8)
- 4,8-Bis(n-octyloxy)-2,6-bis(trimethylstannyl)-benzo[1,2-b:4,5-b']dithiophene (CAS 1098102-95-4)
- DOCP (CAS 1360461-57-9)
- (4,8-Bis((2-ethylhexyl)oxy)benzo[1,2-b:4,5-b']dithiophene-2,6-diyl)bis(trimethylstannane) (CAS 1160823-78-8)
- Valbenazine Impurity 8 (CAS CATO-C4X-33428)
- Lenvatinib Impurity 145 (CAS CATO-C4X-1140145)
- Fluconazole Impurity 59 (CAS CATO-C4X-101959)
- 1-Chloro-2,4-difluoro-3-(trifluoromethoxy)benzene 1261811-61-3 (CAS 1261811-61-3)
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- Tert-butyl 4-(2,2-difluoroethyl)piperazine-1-carboxylate (CAS 1225380-87-9)
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