Dacomitinib Impurity 40 CAS CATO-C4X-208640
| CAS No. | CATO-C4X-208640 |
| Molecular Formula | C15H12ClFN4O |
| Molecular Weight | 318.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Dacomitinib Impurity 40 (CAS CATO-C4X-208640, C15H12ClFN4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dacomitinib Impurity 40 (C15H12ClFN4O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Dacomitinib Impurity 40 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H12ClFN4O |
| Molecular Weight | 318.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Dacomitinib Standards
- Dacomitinib Impurity 31 (CAS CATO-C4X-208631)
- Dacomitinib Impurity 4 (CAS 179552-75-1)
- Dacomitinib Impurity 44 (CAS CATO-C4X-208644)
- Dacomitinib Impurity 43 (CAS CATO-C4X-208643)
- Dacomitinib Impurity 29 (CAS CATO-C4X-208629)
- Dacomitinib Impurity 26 (CAS CATO-C4X-208626)
- Dacomitinib Impurity 30 (CAS CATO-C4X-208630)
- Dacomitinib Impurity 39 (CAS CATO-C4X-208639)
Recommended Standards
- 7-Chloro-3-(dimethylamino)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide (CAS 75787-40-5)
- Flutemazepam (CAS 52391-89-6)
- Ethyl 7-(2-chloro-4,5-difluorophenyl)-7-oxoheptanoate (CAS 951887-29-9)
- 7-Chloro-5-(2-Fluorophenoxy)-1-Methyl-1H-1,4-Benzodiazepin-2(3H)-One (CAS 62903-61-1)
- Sunitinib Impurity 15 (CAS 590424-05-8)
- Atrasentan Impurity 134 (CAS 1058349-07-7)
- Evocalcet Impurity 42 (CAS 2851537-33-0)
- 9-fluoro-3-oxa-7-azabicyclo[3.3.1]nonane (CAS 1341035-38-8)
- 6-(2-(Aziridin-1-yl)ethoxy)-5-bromonicotinic acid (CAS 1216703-32-0)
- Ethyl 3-{[2-(4-chlorobenzoyl)-1-benzofuran-3-yl]methoxy}pyrido[1,2-a]indole-10-carboxylate (CAS 339020-42-7)
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- 4-(2,4-Dichlorophenyl)-5-((4-fluorophenyl)thio)-1,2,3-thiadiazole (CAS 338407-99-1)
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- (Leu31,Pro3?)-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 132699-73-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com