Avatrombopag Impurity 46 CAS CATO-C4X-223446
| CAS No. | CATO-C4X-223446 |
| Molecular Formula | C29H35ClN6O4S2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Avatrombopag Impurity 46 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Avatrombopag Impurity 46 (CAS CATO-C4X-223446, C29H35ClN6O4S2C4H4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Avatrombopag Impurity 46 (C29H35ClN6O4S2C4H4O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H35ClN6O4S2 C4H4O4 |
| Molecular Weight | 747.28 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag Impurity 31 (CAS 1126-09-6)
- Avatrombopag Impurity 52 (CAS 1224935-95-8)
- Avatrombopag Impurity 20 (CAS 123971-45-9)
- Avatrombopag Impurity 43 (CAS 1268118-96-2)
- Avatrombopag Impurity 5 (CAS 1290121-42-4)
- Avatrombopag Impurity 24 (CAS 1534575-19-3)
- Avatrombopag Impurity 92 (CAS 160114-74-9)
- Avatrombopag Impurity 37 (CAS 17766-28-8)
Recommended Standards
- Ciprofloxacin Impurity 50 (CAS CATO-C4X-136250)
- Salbutamol Impurity N19 (CAS 77430-27-4)
- Felbinac Trometamol Impurity 2 (CAS CATO-C4X-33682)
- Methyl 1-(difluoromethyl)-1H-imidazole-5-carboxylate (CAS 2350052-23-0)
- tert-Butyl (2-hydroxyethyl)(3-methylbut-2-en-1-yl)carbamate (CAS 869557-80-2)
- 2-(4-Carbamoylpiperidin-1-yl)-2-phenylacetic acid (CAS 938149-72-5)
- Methyl 3-acetyl-4-isopropoxybenzoate (CAS 259147-67-6)
- 5-methylthiophen-2-amine (CAS 55502-89-1)
- 4-((5-Cyano-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridin-3-yl)diazenyl)benzoic acid (CAS 796874-80-1)
- Semaglutide238 (CAS CATO-C4X-2226238)
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