Venetoclax Impurity 83 CAS CATO-C4X-249583
| CAS No. | CATO-C4X-249583 |
| Molecular Formula | C45H48ClN9O9S |
| Molecular Weight | 926.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Venetoclax Impurity 83.
Venetoclax Impurity 83 (CAS CATO-C4X-249583) is a certified pharmaceutical impurity reference standard with the molecular formula C45H48ClN9O9S and a molecular weight of 926.44 g/mol.
Based on its molecular formula C45H48ClN9O9S, Venetoclax Impurity 83 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 926.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C45H48ClN9O9S |
| Molecular Weight | 926.44 g/mol |
| Purity | ≥98% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 26.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 9 |
| Sulfur Atoms | 1 |
Related Venetoclax Standards
- Venetoclax Impurity 23 (CAS CATO-C4X-249523)
- Venetoclax Impurity 82 (CAS CATO-C4X-249582)
- Venetoclax Impurity 141 (CAS CATO-C4X-2495141)
- Venetoclax Impurity 47 (CAS CATO-C4X-249547)
- Venetoclax Impurity 22 (CAS CATO-C4X-249522)
- Venetoclax Impurity 60 (CAS CATO-C4X-249560)
- Venetoclax Nitroso Impurity 15 (CAS CATO-C4X-249515)
- Venetoclax Impurity 24 (CAS CATO-C4X-249524)
Recommended Standards
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- Bis(4-(3,3,4,4,5,5,5-heptafluoro-2,2-bis(trifluoromethyl)pentyl)phenyl)(phenyl)phosphine (CAS 322647-83-6)
- Latamoxef Impurity 33 (CAS CATO-C4X-179833)
- Finasteride Impurity 52 (CAS CATO-C4X-164552)
- Dopamine Impurity 30 (CAS 339186-39-9)
- Vonoprazan Impurity 43 (CAS 2169271-28-5)
- Titanyl acetylacetonate(IV) (CAS 14024-64-7)
- 6-Pentyl-2H-pyran-2-one (CAS 27593-23-3)
- Propiverine Impurity N1 HCl (CAS 54556-99-9)
- 2-(1h-Pyrazol-1-yl)-N-(thiophen-3-ylmethyl)ethan-1-amine (CAS 1251140-55-2)
- 21102-94-3 08EI0K81OL Bmy 7378 8-Azaspiro(4.5)decane-7,9-dione, 8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)- BMY-7378 8-(2-(4-(2-Methoxyphenyl)-1-piperazinyl)ethyl)-8-azaspiro(4.5)decane-7,9-dione UNII-08EI0K81OL (CAS 21102-94-3)
- 2-(2-Methoxyphenyl)oxazolo[4,5-b]pyridine (CAS 52333-62-7)
- Semaglutide impurity 72 (CAS CATO-C4X-222672)
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