Venetoclax Impurity 23 CAS CATO-C4X-249523
| CAS No. | CATO-C4X-249523 |
| Molecular Formula | C45H48ClN9O9S |
| Molecular Weight | 926.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 926.44 g/mol gives Venetoclax Impurity 23 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Venetoclax Impurity 23 (CAS CATO-C4X-249523) is a certified pharmaceutical impurity reference standard with the molecular formula C45H48ClN9O9S and a molecular weight of 926.44 g/mol.
Venetoclax Impurity 23 (C45H48ClN9O9S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C45H48ClN9O9S |
| Molecular Weight | 926.44 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 26.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 9 |
| Sulfur Atoms | 1 |
Related Venetoclax Standards
- Venetoclax Impurity 82 (CAS CATO-C4X-249582)
- Venetoclax Impurity 83 (CAS CATO-C4X-249583)
- Venetoclax Impurity 141 (CAS CATO-C4X-2495141)
- Venetoclax Impurity 47 (CAS CATO-C4X-249547)
- Venetoclax Impurity 22 (CAS CATO-C4X-249522)
- Venetoclax Impurity 60 (CAS CATO-C4X-249560)
- Venetoclax Nitroso Impurity 15 (CAS CATO-C4X-249515)
- Venetoclax Impurity 24 (CAS CATO-C4X-249524)
Recommended Standards
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- Everolimus Impurity 22 (CAS CATO-C4X-112222)
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- Tobramycin Impurity N2 (CAS 111170-72-0)
- Ketorolac Impurity 42 (CAS 144710-35-0)
- Atrasentan Impurity 193 (CAS CATO-C4X-3347193)
- 5-Amino-1-(4-fluorobenzyl)-N-(m-tolyl)-1H-1,2,3-triazole-4-carboxamide (CAS 899973-09-2)
- 2-(4-Bromo-6-(difluoromethyl)-5-fluoropyridin-3-yl)acetic acid (CAS 1804884-27-2)
- N1-(2,4-Difluorophenyl)-N2-(3-hydroxypropyl)oxalamide (CAS 886900-28-3)
- 2-(2,4-Dichlorophenyl)isonicotinic acid (CAS 1261944-40-4)
- 1-(2,3,4,5-Tetrahydro-1H-benzo[b]azepin-1-yl)ethan-1-one (CAS 19886-89-6)
- (R)-N,N-Dimethyl-1-(morpholin-2-yl)methanamine (CAS 214273-19-5)
- Peptide Impurity 28 (CAS 1350456-64-2)
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