Abemaciclib Impurity 4 CAS CATO-C4X-29374
| CAS No. | CATO-C4X-29374 |
| Molecular Formula | C15H13ClF2N4 |
| Molecular Weight | 322.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Abemaciclib Impurity 4 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Abemaciclib Impurity 4 (CAS CATO-C4X-29374) is a certified pharmaceutical impurity reference standard with the molecular formula C15H13ClF2N4 and a molecular weight of 322.74 g/mol.
The molecular framework of Abemaciclib Impurity 4 (C15H13ClF2N4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Abemaciclib Impurity 4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H13ClF2N4 |
| Molecular Weight | 322.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Abemaciclib Standards
- Abemaciclib Impurity N3 (CAS 1231930-42-9)
- Abemaciclib Impurity N1 (CAS 2177297-46-8)
- Abemaciclib Impurity N7 (CAS 1231930-37-2)
- Abemaciclib Impurity 140 (CAS 2124229-65-6)
- Abemaciclib Impurity 63 (CAS CATO-C4X-293763)
- Abemaciclib Impurity 123 (CAS CATO-C4X-2937123)
- Abemaciclib Impurity 177 (CAS CATO-C4X-2937177)
- Abemaciclib Impurity 167 (CAS CATO-C4X-2937167)
Recommended Standards
- (3Z)-3-{[5-(2-chlorophenyl)furan-2-yl]methylidene}-1,3-dihydro-2-benzofuran-1-one 338786-10-0 6F-035 (CAS 338786-10-0)
- N-(2-acetamidoethyl)-4-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)benzamide (CAS 1119450-85-9)
- (3Z)-3-{[5-(3-chlorophenyl)furan-2-yl]methylidene}-1,3-dihydro-2-benzofuran-1-one 338786-06-4 6F-033 (CAS 338786-06-4)
- 2-(4-Chlorophenyl)-3-(1H-1,2,4-triazol-1-yl)isoquinolin-1(2H)-one (CAS 113293-11-1)
- Atorvastatin EP Impurity G(Calcium Salt) (CAS 887196-29-4)
- Dexmedetomidine Impurity 80 (CAS CATO-C4X-123080)
- Ciclosporin Impurity 19 (CAS CATO-C4X-199819)
- 2-(Naphthalen-1-yl)ethyl quinoline-4-carboxylate (CAS 6318-00-9)
- Methyl 2-(7-Chloro-3-indolyl)-2-oxoacetate (CAS 203719-78-2)
- 3-Amino-2,6-dimethylquinazolin-4(3H)-one (CAS 85516-81-0)
- 62656-85-3 L-(2-~13~C)Alanine DTXSID80583881 (CAS 62656-85-3)
- (2-Methylpyrimidin-5-yl)methanol (CAS 2239-83-0)
- Tedizolid Impurity 90 (CAS CATO-C4X-105490)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com