Abemaciclib Impurity 161 CAS CATO-C4X-2937161
| CAS No. | CATO-C4X-2937161 |
| Molecular Formula | C19H22N6O4 |
| Molecular Weight | 398.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C19H22N6O4, Abemaciclib Impurity 161 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 398.42 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Abemaciclib Impurity 161 (CAS CATO-C4X-2937161, C19H22N6O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22N6O4 |
| Molecular Weight | 398.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Abemaciclib Standards
- Abemaciclib Impurity 57 (CAS CATO-C4X-293757)
- Abemaciclib Impurity 183 (CAS CATO-C4X-2937183)
- Abemaciclib Impurity 12 (CAS 1627082-92-1)
- Abemaciclib Impurity 92 (CAS CATO-C4X-293792)
- Abemaciclib Impurity 54 (CAS CATO-C4X-293754)
- Abemaciclib Impurity 13 (CAS 1648707-16-7)
- Abemaciclib Impurity 145 (CAS CATO-C4X-2937145)
- Abemaciclib Impurity 160 (CAS CATO-C4X-2937160)
Recommended Standards
- Cefmetazole Impurity 16 (CAS CATO-C4X-150716)
- 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(3-(2-fluorophenoxy)propyl)benzamide (CAS 1043374-39-5)
- Valaciclovir Impurity 38 (CAS CATO-C4X-124838)
- 1,1-Dimethylethyl [(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-[(3-fluorophenyl)methyl]ethyl]carbamate (CAS 1201923-48-9)
- Dyclonine Impurity 4 (CAS CATO-C4X-18814)
- Enarodustat Impurity 13 (CAS CATO-C4X-322813)
- Vericiguat Impurity 18 (CAS CATO-C4X-289618)
- 5-(4-Fluorophenyl)nicotinamide (CAS 1356110-50-3)
- 1-Chloro-7-iodoheptane (CAS 99669-96-2)
- tert-Butyl 5-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (CAS 1330764-31-2)
- (6-Nitro-2,3-dihydroimidazo[2,1-b]oxazol-2-yl)methanol, 97% (CAS 73332-78-2)
- (3-exo)-tert-Butyl 3-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate (CAS 273207-58-2)
- 2-[(4-benzyl-5-methyl-1h-imidazol-2-yl)sulfanyl]acetic acid (CAS 790272-24-1)
- TRAF6 Peptide trifluoroacetate salt (CAS 852805-92-6)
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