Abemaciclib Impurity 183 CAS CATO-C4X-2937183
| CAS No. | CATO-C4X-2937183 |
| Molecular Formula | C23H22FN2OP |
| Molecular Weight | 392.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 392.41 g/mol gives Abemaciclib Impurity 183 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Abemaciclib Impurity 183 (CAS CATO-C4X-2937183, C23H22FN2OP) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Abemaciclib Impurity 183 (C23H22FN2OP) contains a steroid core, an amide group, organophosphorus functionality, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Abemaciclib Impurity 183 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H22FN2OP |
| Molecular Weight | 392.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib Impurity 161 (CAS CATO-C4X-2937161)
- Abemaciclib Impurity 160 (CAS CATO-C4X-2937160)
- Abemaciclib Impurity 57 (CAS CATO-C4X-293757)
- Abemaciclib Impurity 3 (CAS CATO-C4X-29373)
- Abemaciclib impurity 112 (CAS CATO-C4X-2937112)
- Abemaciclib Impurity 12 (CAS 1627082-92-1)
- Abemaciclib Impurity 92 (CAS CATO-C4X-293792)
- Abemaciclib Impurity 184 (CAS CATO-C4X-2937184)
Recommended Standards
- Finerenone Impurity 120 (CAS CATO-C4X-2880120)
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- N-Nitroso Ozenoxacin (CAS CATO-C4X-27967)
- (2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-(ethylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 126187-25-5)
- Phenylbutyrate Impurity 7 (CAS 864811-35-8)
- Rifampicin Impurity 4 (CAS 16783-99-6)
- Polmacoxib Impurity 4 Sodium Salt (CAS 1778703-67-5)
- Zederone (CAS 7727-79-9)
- Tert-butyl 6-bromo-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate (CAS 1823313-36-5)
- Enzalutamide Impurity 45 (CAS 1332524-01-2)
- 4-Bromo-2-[(1E)-[(3,5-dimethoxyphenyl)imino]methyl]-6-methoxyphenol (CAS 477848-22-9)
- Crisaborole Impurity 138 (CAS CATO-C4X-2021138)
- 3,7-Bis((E)-2-(anthracen-9-yl)vinyl)-5,5-difluoro-10-(p-tolyl)-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine (CAS 1432580-28-3)
- Tau Peptide (306-317) trifluoroacetate salt (CAS 1003007-59-7)
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