Abemaciclib Impurity 12 CAS 1627082-92-1
| CAS No. | 1627082-92-1 |
| Molecular Formula | C21H18F2N6O |
| Molecular Weight | 408.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Abemaciclib Impurity 12 (CAS 1627082-92-1) is a certified pharmaceutical impurity reference standard with the molecular formula C21H18F2N6O and a molecular weight of 408.40 g/mol.
Structurally, Abemaciclib Impurity 12 (C21H18F2N6O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 408.40 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Abemaciclib Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H18F2N6O |
| Molecular Weight | 408.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Abemaciclib Standards
- Abemaciclib Impurity 92 (CAS CATO-C4X-293792)
- Abemaciclib Impurity 54 (CAS CATO-C4X-293754)
- Abemaciclib Impurity 13 (CAS 1648707-16-7)
- Abemaciclib Impurity 145 (CAS CATO-C4X-2937145)
- Abemaciclib Impurity 57 (CAS CATO-C4X-293757)
- Abemaciclib Impurity 161 (CAS CATO-C4X-2937161)
- Abemaciclib Impurity 10 (CAS CATO-C4X-293710)
- Abemaciclib Impurity 183 (CAS CATO-C4X-2937183)
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