Abemaciclib Impurity 44 CAS CATO-C4X-293744
| CAS No. | CATO-C4X-293744 |
| Molecular Formula | C27H32ClFN8 |
| Molecular Weight | 523.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Abemaciclib Impurity 44 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Abemaciclib Impurity 44 (CAS CATO-C4X-293744, C27H32ClFN8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, Abemaciclib Impurity 44 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 523.05 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H32ClFN8 |
| Molecular Weight | 523.05 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 8 |
Related Abemaciclib Standards
- Abemaciclib Impurity 43 (CAS CATO-C4X-293743)
- Abemaciclib Impurity 134 (CAS CATO-C4X-2937134)
- Abemaciclib Impurity 17 (CAS CATO-C4X-293717)
- Abemaciclib Impurity 18 (CAS CATO-C4X-293718)
- Abemaciclib Impurity 25 (CAS CATO-C4X-293725)
- Abemaciclib Impurity 66 (CAS CATO-C4X-293766)
- Abemaciclib Impurity 68 (CAS 2138499-06-4)
- Abemaciclib Impurity 86 (CAS CATO-C4X-293786)
Recommended Standards
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- Fluticasone Impurity 113 (CAS CATO-C4X-1650113)
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- Capmatinib Impurity 6 (CAS CATO-C4X-29856)
- Trimetazidine impurity 31 (CAS CATO-C4X-180331)
- BPA Impurity 2 (CAS 2828446-99-5)
- Canagliflozin Impurity 44 (CAS CATO-C4X-112344)
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- 2-Methyl-3-morpholino-N-(3-phenylisoxazol-5-yl)propanamide (CAS 86683-57-0)
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