Abemaciclib Impurity 75 CAS CATO-C4X-293775
| CAS No. | CATO-C4X-293775 |
| Molecular Formula | C16H18Br2N4 |
| Molecular Weight | 426.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 426.15 g/mol gives Abemaciclib Impurity 75 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Abemaciclib Impurity 75 (CAS CATO-C4X-293775) is a certified pharmaceutical impurity reference standard with the molecular formula C16H18Br2N4 and a molecular weight of 426.15 g/mol.
Structurally, Abemaciclib Impurity 75 (C16H18Br2N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 426.15 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H18Br2N4 |
| Molecular Weight | 426.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Abemaciclib Standards
- Abemaciclib Impurity 51 (CAS CATO-C4X-293751)
- Abemaciclib Impurity 9 (CAS CATO-C4X-29379)
- Abemaciclib Impurity 34 (CAS CATO-C4X-293734)
- Abemaciclib Impurity 10 (CAS CATO-C4X-293710)
- Abemaciclib Impurity 188 (CAS CATO-C4X-2937188)
- Abemaciclib Impurity 189 (CAS CATO-C4X-2937189)
- Abemaciclib Impurity 41 (CAS CATO-C4X-293741)
- Abemaciclib Impurity 145 (CAS CATO-C4X-2937145)
Recommended Standards
- Wiskostatin (CAS 253449-04-6)
- 2,2'-(5-Hydroxy-1,3-phenylene)bis(1,1,1,3,3,3-hexafluoropropan-2-ol) (CAS 669768-28-9)
- N1-[3,5-di(trifluoromethyl)phenyl]-2-bromo-2-phenylacetamide (CAS 285980-97-4)
- 5-Iodo-2-(3-methyl-4-nitrobenzamido)benzoic acid (CAS 294892-53-8)
- Sitagliptin Impurity 118 (CAS 1261633-32-2)
- Primidone EP impurity A hydrate (CAS 80866-90-6)
- Cefotiam Impurity 49 (CAS CATO-C4X-120449)
- 2-Methyl-3-(2-(pyridin-4-yl)ethyl)indolizine (CAS 10314-96-2)
- 2-Chloro-4-ethoxypyridin-3-amine (CAS 173435-35-3)
- N1-(2-Chlorobenzyl)-N1-ethylethane-1,2-diamine (CAS 61694-80-2)
- (1-(3-Phenylpyrazin-2-yl)piperidin-4-yl)methanamine (CAS 1069473-58-0)
- N-Benzyl-3-(5-(3-nitrophenyl)furan-2-yl)acrylamide (CAS 853351-47-0)
- 1-(4-(2,4-Dichlorophenyl)thiazol-2-yl)-4-(4-methoxyphenyl)-1H-pyrazol-5-amine (CAS 956752-74-2)
- Tirzepatide Impurity 25 X TFA Salt (CAS CATO-C4X-324025)
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