Abemaciclib Impurity 41 CAS CATO-C4X-293741
| CAS No. | CATO-C4X-293741 |
| Molecular Formula | C19H14Cl2F2N6 |
| Molecular Weight | 435.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Abemaciclib Impurity 41 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Abemaciclib Impurity 41 (CAS CATO-C4X-293741, C19H14Cl2F2N6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Abemaciclib Impurity 41 (C19H14Cl2F2N6) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H14Cl2F2N6 |
| Molecular Weight | 435.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Abemaciclib Standards
- Abemaciclib Impurity 188 (CAS CATO-C4X-2937188)
- Abemaciclib Impurity 189 (CAS CATO-C4X-2937189)
- Abemaciclib Impurity 51 (CAS CATO-C4X-293751)
- Abemaciclib Impurity 75 (CAS CATO-C4X-293775)
- Abemaciclib Impurity 9 (CAS CATO-C4X-29379)
- Abemaciclib Impurity 34 (CAS CATO-C4X-293734)
- Abemaciclib Impurity 10 (CAS CATO-C4X-293710)
- Abemaciclib Impurity 145 (CAS CATO-C4X-2937145)
Recommended Standards
- 3,3'-((2,5-Dichloro-1,4-phenylene)bis(azanediyl))bis(1H-isoindol-1-one) (CAS 51016-63-8)
- AM694 3-Iodo Isomer (CAS 1427325-91-4)
- 2-[(4-Bromophenyl)sulfanyl]-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 338749-49-8)
- (1-(5-Fluoropentyl)-1H-indol-3-yl)(4-iodophenyl)methanone (CAS 1427325-92-5)
- Cloransulam-Methyl Impurity 11 (CAS CATO-C4X-317011)
- Ribociclib Impurity 40 (CAS CATO-C4X-310040)
- Lidocaine Impurity 101 (CAS CATO-C4X-1679101)
- (S)-2-(M-TOLYL)PIPERIDINE (CAS 1228568-39-5)
- 3-(3-Hydroxyphenyl)oxetan-3-ol (CAS 1379811-99-0)
- 4-(2-Ethylbutanoyl)-N-[3-(1H-imidazol-1-yl)propyl]-1H-pyrrole-2-carboxamide (CAS 439112-10-4)
- 3-Hydroxymethyl Maraviroc (CAS 1217535-55-1)
- (4-Isothiocyanatophenyl)(2-methylphenyl)amine (CAS 1177331-27-9)
- Pretomanid Impurity 9 (CAS CATO-C4X-26069)
- Semaglutide Impurity 190 (CAS CATO-C4X-2226190)
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