Nebivolol Impurity 2 CAS CATO-C4X-19682
| CAS No. | CATO-C4X-19682 |
| Molecular Formula | C22H26FNO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Nebivolol Impurity 2 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 423.91 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Nebivolol Impurity 2 (CAS CATO-C4X-19682) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26FNO4HCl and a molecular weight of 423.91 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H26FNO4 HCl |
| Molecular Weight | 423.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 66 (CAS 1017878-67-9)
- Nebivolol Impurity 15 (CAS 1029684-20-5)
- Nebivolol Impurity 20 (CAS 105300-40-1)
- Nebivolol Impurity 28 (CAS 112068-01-6)
- D-Nebivolol (SR,RR) (CAS 118457-15-1)
- L-Nebivolol (RS,SS) (CAS 118457-16-2)
- Nebivolol Hydrochloride EP Impurity B (CAS 119365-23-0)
- Nebivolol Impurity 32（SS,RS）or（SR,SS） (CAS 119365-25-2)
Recommended Standards
- Upadacitinib Impurity 18 (CAS 1428243-24-6)
- Vinorelbine EP Impurity I (CAS CATO-C4X-264210)
- Levothyroxine Impurity 15 (CAS CATO-C4X-167815)
- ethyl 3-sulfanylbutanoate (CAS 156472-94-5)
- Methyl 3-(2-ethoxy-2-oxoacetyl)-5,6,7,8-tetrahydroindolizine-1-carboxylate (CAS 2396687-24-2)
- (5-Chloro-2-propoxyphenyl)(methyl)sulfane (CAS 1443355-73-4)
- 1-Benzyl-3-(hydroxymethyl)pyrrolidine-3-carbonitrile (CAS 1350475-49-8)
- Desloratadine USP Related Compound F (CAS 117810-61-4)
- 1-(2-Fluorophenyl)-3-((5-(furan-2-carbonyl)thiophen-2-yl)methyl)urea (CAS 1797614-07-3)
- Semaglutide Impurity 5 (CAS 23406-82-8)
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