Encorafenib Impurity 18 CAS CATO-C4X-324918
| CAS No. | CATO-C4X-324918 |
| Molecular Formula | C21H25ClFN7O2 |
| Molecular Weight | 461.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Encorafenib Impurity 18 (CAS CATO-C4X-324918) is a certified pharmaceutical impurity reference standard with the molecular formula C21H25ClFN7O2 and a molecular weight of 461.92 g/mol.
Encorafenib Impurity 18 (C21H25ClFN7O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H25ClFN7O2 |
| Molecular Weight | 461.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 7 |
Related Encorafenib Standards
- Encorafenib Impurity 11 (CAS CATO-C4X-32411)
- Encorafenib Impurity 10 (CAS 1269440-78-9)
- Encorafenib Impurity 13 (CAS CATO-C4X-324913)
- Encorafenib Impurity 15 (CAS CATO-C4X-324915)
- Encorafenib Impurity 9 (CAS CATO-C4X-32499)
- Encorafenib Impurity 3 (CAS CATO-C4X-32493)
- Encorafenib Impurity 8 (CAS CATO-C4X-32498)
- Encorafenib Impurity 12 (CAS CATO-C4X-324912)
Recommended Standards
- 1-((4-(Tert-butyl)phenyl)sulfonyl)-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine (CAS 260368-22-7)
- 2-((4-(4-Chlorophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(1H-indazol-6-yl)acetamide (CAS 476483-73-5)
- Ticagrelor Impurity 116 (CAS 1863036-47-8)
- MK-5108 (CAS 1010085-13-8)
- Celecoxib Impurity N3 (CAS 877-67-8)
- Loteprednol Impurity 4 (CAS 133991-62-5)
- Bevantolol Impurity 5 (CAS 147220-24-4)
- 3-((3-Amino-3-oxopropyl)amino)propanoic acid (CAS 5493-40-3)
- 2,3,6,7-Tetramethylquinoxaline, 97% (CAS 6957-19-3)
- 2-((2-(Dimethylamino)-2-oxoethyl)amino)benzoic acid (CAS 924846-10-6)
- n-(3-Chlorophenyl)-2-((cyclobutylmethyl)amino)acetamide (CAS 1095505-01-3)
- 5-Amino-2,4-dichlorobenzene-1-sulfonamide (CAS 4818-77-3)
- Benzyl N-[(3R,4R)-3-hydroxypiperidin-4-yl]carbamate (CAS 1638744-48-5)
- Insulin Degludec Impurity 12 (CAS CATO-C4X-215712)
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