Encorafenib Impurity 8 CAS CATO-C4X-32498
| CAS No. | CATO-C4X-32498 |
| Molecular Formula | C14H19IN6O2 |
| Molecular Weight | 430.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Encorafenib Impurity 8 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Encorafenib Impurity 8 (CAS CATO-C4X-32498, C14H19IN6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Encorafenib Impurity 8 (C14H19IN6O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Encorafenib Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H19IN6O2 |
| Molecular Weight | 430.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
| Nitrogen Atoms | 6 |
Related Encorafenib Standards
- Encorafenib Impurity 15 (CAS CATO-C4X-324915)
- Encorafenib Impurity 9 (CAS CATO-C4X-32499)
- Encorafenib Impurity 13 (CAS CATO-C4X-324913)
- Encorafenib Impurity 6 (CAS CATO-C4X-32496)
- Encorafenib Impurity 11 (CAS CATO-C4X-32411)
- Encorafenib Impurity 10 (CAS 1269440-78-9)
- Encorafenib Impurity 18 (CAS CATO-C4X-324918)
- Encorafenib Impurity 3 (CAS CATO-C4X-32493)
Recommended Standards
- Tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate (CAS 461701-17-7)
- (E)-1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorotetradec-7-ene (CAS 113999-58-9)
- Tert-butyl ((1s,3s)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclobutyl)carbamate (CAS 2088762-02-9)
- Ethyl 6-bromo-4-(4-methyl-3-nitrophenylamino)quinoline-3-carboxylate (CAS 1415562-32-1)
- Ibrutinib Impurity 90 (CAS 2417548-81-1)
- Docetaxel Impurity 19 (CAS 146924-91-6)
- Atrasentan Impurity 170 (CAS 1059051-92-1)
- Pantoprazole Impurity 27 (CAS 76015-11-7)
- Disodium Levononidazole Phosphate (CAS 1685275-23-3)
- 2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-methoxypentanoic acid (CAS 1483389-52-1)
- 5-Bromo-1H-imidazo[4,5-b]pyrazine-2(3H)-thione (CAS 2601592-84-9)
- 5,5′-[[4,8-Bis[5-(2-ethylhexyl)-2-thienyl]benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl]bis[(3,3′′-dioctyl[2,2′:5′,2′′-terthiophene]-5′′,5-diyl)methylidyne]]bis[3-octyl-2-thioxo-4-thiazolidinone] (CAS 1651168-29-4)
- ethyl 6-(chloromethyl)-4-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 263157-07-9)
- Insulin Degludec Impurity 9 (CAS CATO-C4X-21579)
Why CATO?
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