Encorafenib Impurity 10 CAS 1269440-78-9

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.1269440-78-9
Molecular FormulaC21H25ClFN7O2
Molecular Weight461.92 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Encorafenib Impurity 10 CAS 1269440-78-9 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 461.92 g/mol gives Encorafenib Impurity 10 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Encorafenib Impurity 10 (CAS 1269440-78-9) is a certified pharmaceutical impurity reference standard with the molecular formula C21H25ClFN7O2 and a molecular weight of 461.92 g/mol.

The molecular framework of Encorafenib Impurity 10 (C21H25ClFN7O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC21H25ClFN7O2
Molecular Weight461.92 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity≥95%
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)12.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1990
Halogen ContentF/Cl-containing
Nitrogen Atoms7

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