Nintedanib Impurity 49 CAS 1168152-07-5
| CAS No. | 1168152-07-5 |
| Molecular Formula | C20H17NO5 |
| Molecular Weight | 351.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 351.35 g/mol gives Nintedanib Impurity 49 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Nintedanib Impurity 49 (CAS 1168152-07-5) is a certified pharmaceutical impurity reference standard with the molecular formula C20H17NO5 and a molecular weight of 351.35 g/mol.
Based on its molecular formula C20H17NO5, Nintedanib Impurity 49 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 351.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H17NO5 |
| Molecular Weight | 351.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 13 (CAS 1253769-13-9)
- Nintedanib Impurity 128 (CAS CATO-C4X-1814128)
- Nintedanib Impurity 119 (CAS CATO-C4X-1814119)
- Nintedanib Impurity 148 (CAS CATO-C4X-1814148)
- Nintedanib Impurity 134 (CAS CATO-C4X-1814134)
- Nintedanib Impurity 99 (CAS CATO-C4X-181499)
- Nintedanib Impurity 162 (CAS CATO-C4X-1814162)
- Nintedanib Impurity 26 (CAS CATO-C4X-181426)
Recommended Standards
- Oxyberberine (CAS 549-21-3)
- Lansoprazole impurity 72 (CAS 2138848-89-0)
- 13-Hydroxyberberine Inner Salt (CAS 62595-72-6)
- Citalopram Impurity 16 (CAS 762266-07-9)
- Rosuvastatin Impurity 200 (CAS CATO-C4X-1169200)
- Desloratadine Impurity 83 (CAS 26699-73-0)
- Chlortalidone EP Impurity D (CAS 1369995-36-7)
- 5-(3-Chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (CAS 1423030-58-3)
- 4-((4-(Tert-butyl)phenyl)amino)-4-oxobutanoic acid (CAS 329079-35-8)
- Verapamil Impurity 20 (CAS 27339-25-9)
- 5-(4-Bromo-2-methoxyphenyl)-3-methyl-1,2,4-oxadiazole (CAS 1469468-58-3)
- (R)-2-(1-Aminoethyl)-4-fluorophenol (CAS 1228570-33-9)
- 6-((3-Chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole hydrochloride (CAS 145858-50-0)
- D-Asp15-Tirzepatide (CAS CATO-CPTD788919)
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