Trazodone Impurity 67 HCl CAS 142944-48-7
| CAS No. | 142944-48-7 |
| Molecular Formula | C13H18BrClN2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Trazodone Impurity 67 HCl (CAS 142944-48-7) is a certified pharmaceutical impurity reference standard with the molecular formula C13H18BrClN2HCl and a molecular weight of 354.11 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution, Trazodone Impurity 67 HCl is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 354.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Trazodone Impurity 67 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H18BrClN2 HCl |
| Molecular Weight | 354.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Trazodone Standards
- Trazodone Impurity N13 (CAS 101364-27-6)
- Trazodone D6 (CAS 1181578-48-2)
- Trazodone-d6 Hydrochloride (CAS 1181578-71-1)
- Trazodone Hydrochloride EP Impurity C (CAS 1263278-77-8)
- Trazodone Impurity 4 (CAS 1263278-79-0)
- Trazodone EP Impurity D HCl (CAS 1263278-80-3)
- Trazodone Hydrochloride EP Impurity J (CAS 1263358-12-8)
- Trazodone EP Impurity D (CAS 1263358-13-9)
Recommended Standards
- Pantoprazole Impurity 53 (CAS 72830-07-0)
- Palonosetron Impurity 9 (CAS 2446343-19-5)
- Efinaconazole Impurity 36 (CAS 6965-45-3)
- 3-(3-Chloro-5-fluorophenyl)prop-2-yn-1-ol (CAS 215054-57-2)
- N1-{2-methyl-4-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]phenyl}-2-chloroacetamide (CAS 299207-95-7)
- N-((5-Bromofuran-2-yl)methyl)-N,N-dimethyl-6-(2,4,6-tribromophenoxy)hexan-1-aminium bromide (CAS 60724-11-0)
- 1-(2-(o-Tolyloxy)ethyl)-1H-benzo[d]imidazol-2-amine (CAS 342398-08-7)
- N-(2-(phenylthio)ethyl)prop-2-en-1-amine (CAS 188642-29-7)
- (S)-6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 314019-11-9)
- Peptide Impurity 09 X TFA Salt (CAS CATO-CPTD788809)
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