Levothyroxine Impurity 20 CAS 2230724-39-5
| CAS No. | 2230724-39-5 |
| Molecular Formula | C15H13I4NO2 |
| Molecular Weight | 746.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Levothyroxine Impurity 20 (C15H13I4NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 746.89 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Levothyroxine Impurity 20 (CAS 2230724-39-5) is a certified pharmaceutical impurity reference standard with the molecular formula C15H13I4NO2 and a molecular weight of 746.89 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Levothyroxine Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H13I4NO2 |
| Molecular Weight | 746.89 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Related Levothyroxine Standards
- Levothyroxine Impurity 26 (CAS 176258-88-1)
- Levothyroxine EP Impurity D (CAS 67-30-1)
- Levothyroxine EP Impurity H (CAS 2055-97-2)
- Levothyroxine lmpurity 45 (CAS CATO-C4X-167845)
- Levothyroxine Related Compound (CAS 93647-48-4)
- Levothyroxine Impurity 41 (CAS 2055-94-9)
- Levothyroxine Impurity 44 (CAS 176258-89-2)
- Levothyroxine EP Impurity I (CAS 2016-06-0)
Recommended Standards
- 1,1′-[(6R,8R,13aS)-3,11-Bis(1,1-dimethylethyl)-7,8-dihydro-6,8-dimethyl-6H-dibenzo[f,h][1,5]dioxonin-1,13-diyl]bis[1,1-diphenylphosphine] (CAS 1048328-92-2)
- (Des-Ala3)-GHRP-2 H-D-Ala-D-2-Nal-Trp-D-Phe-Lys-NH2 (CAS 290312-22-0)
- T4-Formic acid N-methylamide (CAS 2088032-78-2)
- 1-(7-([9,9'-Bianthracen]-10-yl)-9,9-dimethyl-9H-fluoren-2-yl)pyrene (CAS 1705571-70-5)
- Regadenoson Impurity 60 (CAS CATO-C4X-198560)
- N-Notroso Piperacillin impurity 105 (CAS CATO-C4X-1732105)
- Olopatadine Impurity 14 (CAS 1628639-06-4（free base）)
- 4-(3,5-Dichloro-4-fluorophenyl)thiosemicarbazide (CAS 1263376-44-8)
- 2-Bromo-3-(1-naphthyl)-1-propene (CAS 116545-04-1)
- 5-(5-Bromo-2-furyl)-3-methyl-1,2,4-oxadiazole (CAS 1283108-32-6)
- 1-Ethyl-3-(trifluoromethyl)benzene (CAS 27190-70-1)
- 1-(2,4-Dichlorobenzyl)-3-(4-ethyl-5-((2-oxo-2-phenylethyl)thio)-4H-1,2,4-triazol-3-yl)pyridin-2(1H)-one (CAS 477853-24-0)
- 4-Methoxy-2-nitrobenzamide (CAS 33844-22-3)
- Semaglutide impurity 273 (CAS CATO-C4X-2226273)
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