Levothyroxine lmpurity 45 CAS CATO-C4X-167845
| CAS No. | CATO-C4X-167845 |
| Molecular Formula | C14H8I4O3 |
| Molecular Weight | 731.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Levothyroxine lmpurity 45 (CAS CATO-C4X-167845, C14H8I4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, a polycyclic aromatic system, Levothyroxine lmpurity 45 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 731.83 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Levothyroxine lmpurity 45 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H8I4O3 |
| Molecular Weight | 731.83 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
Related Levothyroxine Standards
- Levothyroxine EP Impurity H (CAS 2055-97-2)
- Levothyroxine Impurity 41 (CAS 2055-94-9)
- Levothyroxine Impurity 44 (CAS 176258-89-2)
- Levothyroxine EP Impurity I (CAS 2016-06-0)
- Levothyroxine Impurity 26 (CAS 176258-88-1)
- Levothyroxine Impurity 20 (CAS 2230724-39-5)
- Levothyroxine EP Impurity D (CAS 67-30-1)
- Levothyroxine Related Compound (CAS 93647-48-4)
Recommended Standards
- Danoprevir (CAS 850876-88-9)
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- N-Benzoyl-5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-(2-methoxyethyl)-adenosine (CAS 251647-48-0)
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- 4-Methoxy-N-methylbenzenesulfonamide (CAS 7010-86-8)
- Butalbital Impurity 4 (CAS 53943-64-9)
- ((1R,7a'S)-2,2-Difluorodihydro-1'H,3'H-spiro[cyclopropane-1,2'-pyrrolizin]-7a'(5'H)-yl)methanol (CAS 2850327-37-4)
- Amlodipine 131 (CAS CATO-C4X-1095131)
- 4-(chloromethyl)-3-fluoro-pyridine hydrochloride (CAS 1357351-91-7)
- Palmitoyl Tripeptide-1 TFA salt (CAS 2803375-47-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com