Levothyroxine EP Impurity I CAS 2016-06-0
| CAS No. | 2016-06-0 |
| Molecular Formula | C13H6I4O3 |
| Molecular Weight | 717.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Levothyroxine EP Impurity I (CAS 2016-06-0), a pharmacopoeial impurity reference standard (molecular formula C13H6I4O3, MW 717.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Levothyroxine EP Impurity I (C13H6I4O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H6I4O3 |
| Molecular Weight | 717.80 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
Related Levothyroxine Standards
- Levothyroxine Impurity 44 (CAS 176258-89-2)
- Levothyroxine Impurity 41 (CAS 2055-94-9)
- Levothyroxine lmpurity 45 (CAS CATO-C4X-167845)
- Levothyroxine EP Impurity H (CAS 2055-97-2)
- Levothyroxine Impurity 26 (CAS 176258-88-1)
- Levothyroxine Impurity 20 (CAS 2230724-39-5)
- Levothyroxine EP Impurity D (CAS 67-30-1)
- Levothyroxine Impurity 25 (CAS CATO-C4X-167825)
Recommended Standards
- Eravacycline impurity 39 (CAS CATO-C4X-293839)
- Atorvastatin EP Impurity F (CAS 1371615-56-3)
- 5,10,15,20-tetraphenyl-21<I>H</I>,23<I>H</I>-nickel porphine(II) (CAS 14172-92-0)
- Atorvastatin Calcium EP Impurity F (CAS 887196-24-9)
- Valsartan Impurity 117 (CAS CATO-C4X-1057117)
- Vasopressin Impurity 1 ·xTFA salt (CAS CATO-C4X-23651)
- Aripiprazole Impurity 13 (CAS 573691-11-9)
- 2,6-Difluorocinnamaldehyde (CAS 117338-43-9)
- dimethyl 1,3-dimethylcyclopentane-1,3-dicarboxylate (CAS 546101-12-6)
- n-(1-(2-Aminoethyl)piperidin-4-yl)butyramide (CAS 1341105-81-4)
- 4-Benzyloxy-5-methoxy-2-nitrotoluene (CAS 121086-26-8)
- 273196-04-6 6,7-Dimethyl-3-(2-oxo-2-phenyl-ethylidene)-3,4-dihydro-1H-quinoxalin-2-one (CAS 273196-04-6)
- (2R,3R,4R,5R,6R)-5-acetamido-2-(acetoxymethyl)-6-(benzyloxy)tetrahydro-2H-pyran-3,4-diyl diacetate (CAS 41355-94-6)
- Semaglutide impurity 250 (CAS CATO-C4X-2226250)
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