Levothyroxine EP Impurity D CAS 67-30-1
| CAS No. | 67-30-1 |
| Molecular Formula | C14H8I4O4 |
| Molecular Weight | 747.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Levothyroxine EP Impurity D (C14H8I4O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, a polycyclic aromatic system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Levothyroxine EP Impurity D (CAS 67-30-1, C14H8I4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Levothyroxine EP Impurity D under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H8I4O4 |
| Molecular Weight | 747.83 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
Related Levothyroxine Standards
- Levothyroxine Impurity 20 (CAS 2230724-39-5)
- Levothyroxine Impurity 26 (CAS 176258-88-1)
- Levothyroxine EP Impurity H (CAS 2055-97-2)
- Levothyroxine Related Compound (CAS 93647-48-4)
- Levothyroxine lmpurity 45 (CAS CATO-C4X-167845)
- Levothyroxine Impurity 41 (CAS 2055-94-9)
- Levothyroxine Impurity 44 (CAS 176258-89-2)
- Levothyroxine Impurity 20 (CAS 7069-47-8)
Recommended Standards
- Boc-Phe-(Alloc)Lys-PAB-PNP (CAS 1160844-44-9)
- LH-RH(4-10) (CAS 51776-33-1)
- Rylugolimid Disubstituents (CAS CATO-C4X-2429151)
- Alvimopan impurity 20 (CAS CATO-C4X-114520)
- Alogliptin Impurity 41 (CAS 3177-80-8)
- Isoprenaline Hydrochloride EP Impurity A (CAS 16899-81-3)
- Peramivir Impurity 14 (CAS 2124296-37-1)
- R-4-Hydroxyphenylglycine ethyl ester hydrochloride (CAS 54477-22-4)
- Vonoprazan Impurity 130 (CAS 881674-06-2)
- Lanthanum(III) hydroxide (CAS 14507-19-8)
- 7-Bromo-1H-pyrazolo[4,3-b]pyridine (CAS 1256806-33-3)
- 5-PAHSA (CAS 1481636-41-2)
- 3-Amino-4-chloro-N-[3-(dimethylamino)propyl]-benzenesulfonamide hydrochloride (CAS 1219976-45-0)
- Semaglutide Impurity 183 (CAS 159541-28-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com