Levothyroxine Impurity 26 CAS 176258-88-1

Description

Compared with other compounds in its class, the molecular weight of 746.84 g/mol gives Levothyroxine Impurity 26 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Levothyroxine Impurity 26 (CAS 176258-88-1), a pharmacopoeial impurity reference standard (molecular formula C14H9I4NO3, MW 746.84 g/mol) used for the identification and quantification of trace impurities in APIs.

Levothyroxine Impurity 26 (C14H9I4NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

CATO manufactures Levothyroxine Impurity 26 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Why CATO?

• ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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