Levothyroxine Impurity 44 CAS 176258-89-2
| CAS No. | 176258-89-2 |
| Molecular Formula | C14H10I4O2 |
| Molecular Weight | 717.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Levothyroxine Impurity 44 (C14H10I4O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Levothyroxine Impurity 44 (CAS 176258-89-2, C14H10I4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Levothyroxine Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H10I4O2 |
| Molecular Weight | 717.85 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | I-containing |
Related Levothyroxine Standards
- Levothyroxine EP Impurity I (CAS 2016-06-0)
- Levothyroxine Impurity 41 (CAS 2055-94-9)
- Levothyroxine lmpurity 45 (CAS CATO-C4X-167845)
- Levothyroxine EP Impurity H (CAS 2055-97-2)
- Levothyroxine Impurity 26 (CAS 176258-88-1)
- Levothyroxine Impurity 20 (CAS 2230724-39-5)
- Levothyroxine EP Impurity D (CAS 67-30-1)
- Levothyroxine Impurity 25 (CAS CATO-C4X-167825)
Recommended Standards
- 2,3,6,7,12,13,16,17-Octahydro-9-[4-[[[2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl]amino]sulfonyl]-2-sulfophenyl]-1H,5H,11H,15H-xantheno[2,3,4-ij:5,6,7-i'j']diquinolizin-18-ium Inner Salt (CAS 386229-75-0)
- Ga(III) meso-Tetraphenylporphine chloride (CAS 78833-52-0)
- t-Boc-N-amido-PEG-acid 3000 (CAS 187848-68-6)
- Argatroban Impurity 99 (CAS CATO-C4X-100799)
- Lifitegrast Impurity 37 (CAS 1194550-56-5)
- Esomeprazole Impurity 131 (CAS CATO-C4X-1112131)
- Lifitegrast Impurity 82 (CAS CATO-C4X-240982)
- 5-Phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline (CAS 248603-38-5)
- 1774895-99-6 tert-Butyl 4-(2-bromo-6-(trifluoromethyl)-phenyl)piperazine-1-carboxylate (CAS 1774895-99-6)
- 3'-Ethyl-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]-4'-one (CAS 866010-37-9)
- (S)-2-Amino-3-(4-chloro-2-fluorophenyl)propanoic acid (CAS 185837-15-4)
- 3,7-Dichloro-1,1,1,3,5,5,5,7-octafluoro-4,8-diiodo-5lambda5-octane (CAS 885275-78-5)
- tert-Butyl (2-(3-nitrophenoxy)ethyl)carbamate (CAS 246240-09-5)
- Fas C- Terminal Tripeptide (CAS 189109-90-8)
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