Aprepitant impurity 49 CAS 2475187-95-0
| CAS No. | 2475187-95-0 |
| Molecular Formula | C20H18F7NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 473.81 g/mol gives Aprepitant impurity 49 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Aprepitant impurity 49 (CAS 2475187-95-0) is a certified pharmaceutical impurity reference standard with the molecular formula C20H18F7NO2HCl and a molecular weight of 473.81 g/mol.
Structurally, Aprepitant impurity 49 (C20H18F7NO2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 473.81 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H18F7NO2 HCl |
| Molecular Weight | 473.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant D4 (CAS 1133387-60-6)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
Recommended Standards
- Norethindrone Impurity 6 (CAS 6424-05-1)
- Ketoconazole Impurity 7 (CAS 172032-21-2)
- Ziprasidone Impurity 11 (CAS 188797-76-4)
- (1-Ethyl-1H-imidazol-2-yl)(tetrahydro-2H-pyran-3-yl)methanone (CAS 1482318-94-4)
- 2-(3-methylbutyl)piperidine hydrochloride (CAS 14162-70-0)
- 2-(2,2-Difluoroethoxy)-2-methylpropanoic Acid (CAS 1447942-42-8)
- 1,3,5-trichloro-2-isothiocyanatobenzene 2,4,6-Trichlorophenyl isothiocyanate 22134-07-2 (CAS 22134-07-2)
- 7-Methoxy-1H-benzo[d]imidazole-6-carboxylic acid (CAS 1360954-54-6)
- 5-Amino-6-methylpyrimidin-4-ol (CAS 14675-49-1)
- Neuropeptide SF (human) (CAS 192387-39-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com