Trazodone EP Impurity A HCl CAS 55290-66-9
| CAS No. | 55290-66-9 |
| Molecular Formula | C19H22ClN5O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trazodone EP Impurity A HCl.
Trazodone EP Impurity A HCl (CAS 55290-66-9) is a certified pharmaceutical impurity reference standard with the molecular formula C19H22ClN5O2HCl and a molecular weight of 424.33 g/mol.
Based on its molecular formula C19H22ClN5O2HCl, Trazodone EP Impurity A HCl contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 424.33 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22ClN5O2 HCl |
| Molecular Weight | 424.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Trazodone Standards
- Trazodone Impurity N13 (CAS 101364-27-6)
- Trazodone D6 (CAS 1181578-48-2)
- Trazodone-d6 Hydrochloride (CAS 1181578-71-1)
- Trazodone Hydrochloride EP Impurity C (CAS 1263278-77-8)
- Trazodone Impurity 4 (CAS 1263278-79-0)
- Trazodone EP Impurity D HCl (CAS 1263278-80-3)
- Trazodone Hydrochloride EP Impurity J (CAS 1263358-12-8)
- Trazodone EP Impurity D (CAS 1263358-13-9)
Recommended Standards
- Prasugrel Impurity 29 HCl (CAS 201049-78-7(free base))
- Palbociclib Impurity 20 (CAS CATO-C3D-1542)
- Melatonin impurity 16 (CAS 203442-76-6)
- 3-Amino-3-methyl-1-pyrrolidino-1-butanone Hydrochloride (CAS 1246471-46-4)
- (3R,5R)-5-Methylpiperidine-3-carboxylic acid (CAS 1638744-76-9)
- Famotidine Impurity 11 (CAS 90237-03-9)
- 3,5-Diiodo-4-methyl-1H-pyrazole (CAS 866639-16-9)
- 2,3,4,5-Tetrahydropyrazolo[1,5-b][1,2]oxazepine-7-carboxylic acid (CAS 1934470-69-5)
- trans-2-(4-(Dimethylamino)phenyl)cyclopentanol (CAS 933674-37-4)
- Semaglutide Impurity 149 (CAS CATO-C4X-2226149)
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