Canagliflozin Impurity 81 CAS CATO-C4X-112381
| CAS No. | CATO-C4X-112381 |
| Molecular Formula | C18H14FIS |
| Molecular Weight | 408.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 408.27 g/mol gives Canagliflozin Impurity 81 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Canagliflozin Impurity 81 (CAS CATO-C4X-112381, C18H14FIS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Canagliflozin Impurity 81 (C18H14FIS) contains sulfur-containing functionality, fluorine/iodine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 408.27 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Canagliflozin Impurity 81 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H14FIS |
| Molecular Weight | 408.27 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/I-containing |
| Sulfur Atoms | 1 |
Related Canagliflozin Standards
- Canagliflozin Impurity 20 (CAS CATO-C4X-112320)
- Canagliflozin Impurity 27 (CAS 898566-17-1)
- Canagliflozin Impurity 51 (CAS 2444540-10-5)
- Canagliflozin Impurity 52 (CAS CATO-C4X-112352)
- Canagliflozin Impurity 53 (CAS CATO-C4X-112353)
- Canagliflozin Impurity 54 (CAS CATO-C4X-112354)
- Canagliflozin Impurity 55 (CAS CATO-C4X-112355)
- Canagliflozin Impurity 76 (CAS 2952941-15-8)
Recommended Standards
- Canagliflozin Impurity 80 (CAS CATO-C4X-112380)
- Canagliflozin Impurity 82 (CAS CATO-C4X-112382)
- Canagliflozin Impurity 77 (CAS CATO-C4X-112377)
- Canagliflozin Impurity 83 (CAS CATO-C4X-112383)
- Isavuconazole Impurity 236 (CAS CATO-C4X-1236236)
- Naltrexone impurity 52 (CAS CATO-C4X-147552)
- Droperidol Impurity 7 (CAS 60373-71-9)
- Febuxostat Impurity 112 (CAS CATO-C4X-1162112)
- (2-Methyl-3,5-dinitrophenyl)boronic acid (CAS 24341-76-2)
- 2-(4-Chlorophenyl)-1H-pyrrole-3-carbonitrile (CAS 122453-02-5)
- Tiapride hydrochloride (CAS 51012-33-0)
- 3-(Cyclopropylmethyl)-1-methyl-1h-pyrazol-5-amine (CAS 1249335-32-7)
- 4-Methylthiophene-3-carboxamide (CAS 189330-32-3)
- Semaglutide impurity 229 (CAS CATO-C4X-2226229)
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